Phospho-Sulindac

 

Topically Applied Phospho-Sulindac Hydrogel is Efficacious and Safe in the Treatment of Experimental Arthritis in Rats. Mattheolabakis G et al. Pharm Res. 2013; 30:1471-82

 

The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats. Huang L et al. Br J Pharmacol. 2011; 162:1521-33.

 

Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice. Mackenzie GG et al. Gastroenterology. 2010 Oct; 139(4):1320-32.

 

Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles. Zhu R et al. Pharm Res. 2012; 29(11):3090-101.

 

The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. Xie G et al. Br J Pharmacol. 2012; 165(7):2152-66.

 

Aerosol administration of phospho-sulindac inhibits lung tumorigenesis. Cheng KW et al.

Mol Cancer Ther. 2013;12(8):1417-28

 

Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds. Huang L et al. Cancer Res. 2011; 71:7617-27

 

Phospho-Ibuprofen

 

Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system. Sun Y et al. Breast Cancer Res. 2012; 14(1):R20.

 

Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts. Zhu C et al. Stem Cells. 2012; 30(10):2065-75.

 

Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds. Huang L et al. Cancer Res. 2011; 71:7617-27

 

Phospho-Valproic Acid

 

Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. Mackenzie GG et al.  PLoS One. 2013 1;8(5):e61532.

 

Mechanism of Action

 

Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents. Sun Y, et al. J Pharmacol Exp Ther. 2011; 338:775-83.

 

The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Sun Y, Rigas B. Cancer Res. 2008; 68(20):8269-77.